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Article Publish Status: FREE
Abstract Title:

Inhibition of Nickel Nanoparticles-Induced Toxicity by Epigallocatechin-3-Gallate in JB6 Cells May Be through Down-Regulation of the MAPK Signaling Pathways.

Abstract Source:

PLoS One. 2016 ;11(3):e0150954. Epub 2016 Mar 4. PMID: 26943640

Abstract Author(s):

Yuanliang Gu, Yafei Wang, Qi Zhou, Linda Bowman, Guochuan Mao, Baobo Zou, Jin Xu, Yu Liu, Kui Liu, Jinshun Zhao, Min Ding

Article Affiliation:

Yuanliang Gu

Abstract:

With the rapid development in nanotechnology, nickel nanoparticles (Ni NPs) have emerged in the application of nanomedicine in recent years. However, the potential adverse health effects of Ni NPs are unclear. In this study, we examined the inhibition effects of epigallocatechin-3-gallate (EGCG) on the toxicity induced by Ni NPs in mouse epidermal cell line (JB6 cell). MTT assay showed that Ni NPs induced cytotoxicity in a dose-dependent manner while EGCG exerted a certain inhibition on the toxicity. Additionally, EGCG could reduce the apoptotic cell number and the level of reactive oxygen species (ROS) in JB6 cells induced by Ni NPs. Furthermore, we observed that EGCG could down-regulate Ni NPs-induced activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) activation in JB6 cells, which has been shown to play pivotal roles in tumor initiation, promotion and progression. Western blot indicated that EGCG could alleviate the toxicity of Ni NPs through regulating protein changes in MAPK signaling pathways. In summary, our results suggest thatcareful evaluation on the potential health effects of Ni NPs is necessary before being widely used in the field of nanomedicine. Inhibition of EGCG on Ni NPs-induced cytotoxicity in JB6 cells may be through the MAPK signaling pathways suggesting that EGCG might be useful in preventing the toxicityof Ni NPs.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Cytoprotective : CK(190) : AC(94)
Problem Substances : Nanoparticles : CK(35) : AC(24)
Adverse Pharmacological Actions : Cytotoxic : CK(89) : AC(53)

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Sayer Ji
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