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Article Publish Status: FREE
Abstract Title:

Elevated maternal C-reactive protein and autism in a national birth cohort.

Abstract Source:

Mol Psychiatry. 2014 Feb ;19(2):259-64. Epub 2013 Jan 22. PMID: 23337946

Abstract Author(s):

A S Brown, A Sourander, S Hinkka-Yli-Salomäki, I W McKeague, J Sundvall, H-M Surcel

Article Affiliation:

A S Brown

Abstract:

Autism is a complex neuropsychiatric syndrome with a largely unknown etiology. Inflammation during pregnancy may represent a common pathway by which infections and other insults increase risk for the disorder. Hence, we investigated the association between early gestational C-reactive protein (CRP), an established inflammatory biomarker, prospectively assayed in maternal sera, and childhood autism in a large national birth cohort with an extensive serum biobank. Other strengths of the cohort included nearly complete ascertainment of pregnancies in Finland (N=1.2 million) over the study period and national psychiatric registries consisting of virtually all treated autism cases in the population. Increasing maternal CRP levels, classified as a continuous variable, were significantly associated with autism in offspring. For maternal CRP levels in the highest quintile, compared with the lowest quintile, there was a significant, 43% elevated risk. This finding suggests that maternal inflammation may have a significant role in autism, with possible implications for identifying preventive strategies and pathogenic mechanisms in autism and other neurodevelopmental disorders.

Study Type : Human Study

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Sayer Ji
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