Estradiol may have proinflammatory effects in older men with coronary artery disease. - GreenMedInfo Summary

Abstract Title:

Relation between markers of inflammation and estradiol in older men.

Abstract Source:

Med Sci Monit. 2010 Dec;16(12):CR593-7. PMID: 21119577

Abstract Author(s):

Wojciech Barud, Robert Palusinski, Jerzy Beltowski, Grazyna Wojcicka, Wojciech Myslinski, Andrzej Grzybowski, Boguslaw Makaruk, Jolanta Mieczkowska, Jerzy Mosiewicz

Article Affiliation:

Department of Internal Medicine, Medical University in Lublin, Lublin, Poland.

Abstract:

BACKGROUND: Inflammation plays a key role in the development of atherosclerosis. Studies in women receiving estrogens show their proinflammatory effects. This study sought to determine relation between sex hormones and 2 inflammation markers: C-reactive protein and fibrinogen.

MATERIAL/METHODS: One hundred men of at least age 50 years were enrolled in the study. Plasma levels of total testosterone, estradiol, sex hormone binding globulin, high-sensitivity C-reactive protein, and fibrinogen were measured. Free estradiol and free testosterone were calculated.

RESULTS: Estradiol and free estradiol levels were positively correlated with C-reactive protein and fibrinogen. In a subgroup analysis, this association persisted only in patients with stable coronary artery disease. No significant correlations were found between testosterone, free testosterone, sex hormone binding globulin, and markers of inflammation.

CONCLUSIONS: This study suggests that estradiol may have proinflammatory effects in older men with coronary artery disease.

Article Published Date : Dec 01, 2010
Study Type : Human Study
Additional Links
Diseases : C-Reactive Protein : CK(3134) : AC(371), Coronary Artery Disease : CK(2089) : AC(266), Estrogen Dominance : CK(107) : AC(39)
Additional Keywords : Sex Hormone-Binding Globulin : CK(150) : AC(15)

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Key Research Topics

Disease

C-Reactive Protein
Estrogen Dominance
Coronary Artery Disease

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