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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

ANTI-TOXOPLASMA ACTIVITY OF ESTRAGOLE AND THYMOL IN MURINE MODELS OF CONGENITAL AND NON-CONGENITAL TOXOPLASMOSIS.

Abstract Source:

J Parasitol. 2016 Feb 2. Epub 2016 Feb 2. PMID: 26836848

Abstract Author(s):

Clà Udio B Silva Oliveira, Ywlliane S R Meurer, Thales L Medeiros, Adrian M Pohlit, Murilo V Silva, Tiago W P Mineo, Valter Ferreira Andrade-Neto

Article Affiliation:

Clà Udio B Silva Oliveira

Abstract:

Toxoplasmosis is caused by Toxoplasma gondii an obligatory intracellular protozoan. Normally benign, T. gondii infections can cause devastating disease in immunosuppressed patients and through congenital infection of newborn babies. Few prophylactic and therapeutic drugs are available to treat these infections. The goal of the present study was to assess the anti-Toxoplasma effects in a congenital and non-congenital model of toxoplasmosis (using ME49 strain), besides assessing immunological changes, in vitro cytotoxicity and in vivo acute toxicity of commercial estragole and thymol. The congenital experimental model was used with intermediate stages of maternal infection. The serum levels of IgM, IgG, IL-10, IL-12 and IFN-γ were quantified from infected and treated C57Bl/6 mice. Estragole and thymol respectively exhibited low-to-moderate in vivo toxicity and cytotoxicity. Animals treated with estragol showed high IFN-γ and strong Th1 response. Both compounds were active against T. gondii ME49 strain. Furthermore, orally administered estragole in infected pregnant mice improved the weight of offspring compared to untreated controls. Subcutaneous administration of both compounds also increased the weight of mouse offspring born to infected mothers compared to untreated controls. Estragole and thymol displayimportant anti-Toxoplasma activity. Further studies are needed to elucidate the mechanism of action of these compounds.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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