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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis.

Abstract Source:

Sci Rep. 2017 Feb 1 ;7:40744. Epub 2017 Feb 1. PMID: 28145454

Abstract Author(s):

Kriti Dubey, Bibin G Anand, Dolat Singh Shekhawat, Karunakar Kar

Article Affiliation:

Kriti Dubey

Abstract:

Eugenol has attracted considerable attention because of its potential for many pharmaceutical applications including anti-inflammatory, anti-tumorigenic and anti-oxidant properties. Here, we have investigated the effect of eugenol on amyloid formation of selected globular proteins. We find that both spontaneous and seed-induced aggregation processes of insulin and serum albumin (BSA) are significantly suppressed in the presence of eugenol. Isothermal titration calorimetric data predict a single binding site for eugenol-insulin complex confirming the affinity of eugenol for native soluble insulin species. We also find that eugenol suppresses amyloid-induced hemolysis. Our findings reveal the inherent ability of eugenol to stabilize native proteins and to delay the conversion of protein species of native conformation intoβ-sheet assembled mature fibrils, which seems to be crucial for its inhibitory effect.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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