Extracts of Ficus carica and Perilla frutescens have potential for attenuating pathogens. - GreenMedInfo Summary

Abstract Title:

Bacterial Quorum Sensing Inhibition Activity of the Traditional Chinese Herbs, Ficus carica L. and Perilla frutescens.

Abstract Source:

Chemotherapy. 2014 ;60(5-6):379-83. Epub 2015 Oct 24. PMID: 26496663

Abstract Author(s):

Shiwei Sun, Hui Li, Wanlong Zhou, Ao Liu, Hu Zhu

Article Affiliation:

Shiwei Sun

Abstract:

BACKGROUND: Quorum sensing (QS), as the basis of bacterial cell-to-cell communication, is a promising approach to reduce the incidence of multidrug resistance. The objective of this study was to search for novel quorum sensing inhibitors from plants and control detrimental infections.

METHODS: The crude extracts of Ficus carica and Perilla frutescens were examined for their anti-QS properties. Powdered plant samples were treated sequentially with organic solvents of increasing polarity. The extracts of each solvent were concentrated in vacuo to give crude extracts and tested against Chromobacterium violaceum CV026 and Pseudomonas aeruginosa PA01 especially. Anti-QS activity was measured by quantifying violacein production and swarming motility.

RESULTS: All extracts of these two plants display anti-QS ability. Interestingly, the extract of F. carica with dichloromethane and of P. frutescens with MeOH exhibited the most pronounced inhibition of QS activity.

CONCLUSIONS: These two plants can offer bioactive natural products with potential for attenuating pathogens.

Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Fig : CK(145) : AC(82), Perilla : CK(89) : AC(86)
Diseases : Gram-Negative Bacterial Infections : CK(105) : AC(93), Pseudomonas aeruginosa : CK(304) : AC(334)
Pharmacological Actions : Anti-Bacterial Agents : CK(2894) : AC(1816)
Additional Keywords : Gene Expression Regulation : CK(1387) : AC(612), Multidrug Resistance : CK(25) : AC(16), Plant Extracts : CK(17959) : AC(6472)

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Key Research Topics

Disease

Gram-Negative Bacterial Infections
Pseudomonas aeruginosa

Pharmacological Actions

Anti-Bacterial Agents

Substance

Fig
Perilla

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