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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera.

Abstract Source:

Food Chem Toxicol. 2009 Jun;47(6):1109-16. PMID: 19425184

Abstract Author(s):

Brahma N Singh, B R Singh, R L Singh, D Prakash, R Dhakarey, G Upadhyay, H B Singh

Abstract:

The aqueous extract of leaf (LE), fruit (FE) and seed (SE) of Moringa oleifera was assessed to examine the ability to inhibit the oxidative DNA damage, antioxidant and anti-quorum sensing (QS) potentials. It was found that these extracts could significantly inhibit the OH-dependent damage of pUC18 plasmid DNA and also inhibit synergistically with trolox, with an activity sequence of LE > FE > SE. HPLC and MS/MS analysis was carried out, which showed the presence of gallic acid, chlorogenic acid, ellagic acid, ferulic acid, kaempferol, quercetin and vanillin. The LE was with comparatively higher total phenolics content (105.04 mg gallic acid equivalents (GAE)/g), total flavonoids content (31.28 mg quercetin equivalents (QE)/g), and ascorbic acid content (106.95 mg/100 g) and showed better antioxidant activity (85.77%), anti-radical power (74.3), reducing power (1.1 ascorbic acid equivalents (ASE)/ml), inhibition of lipid peroxidation, protein oxidation, OH-induced deoxyribose degradation, and scavenging power of superoxide anion and nitric oxide radicals than did the FE, SE and standard alpha-tocopherol. Eventually, LE and FE were found to inhibit violacein production, a QS-regulated behavior in Chromobacterium violaceum 12472.

Study Type : In Vitro Study

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Depression: 21st Century Solutions + The Dark Side of Wheat

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