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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1.

Abstract Source:

Arterioscler Thromb Vasc Biol. 2008 Apr ;28(4):739-45. Epub 2008 Jan 17. PMID: 18202320

Abstract Author(s):

Chih-Ching Lin, Xiao-Ming Liu, Kelly Peyton, Hong Wang, Wu-Chang Yang, Shing-Jong Lin, William Durante

Article Affiliation:

Chih-Ching Lin

Abstract:

OBJECTIVE: Survival of arteriovenous fistulas (AVFs) in hemodialysis patients is associated with both far infrared (FIR) therapy and length polymorphisms of the heme oxygenase-1 (HO-1) promoter. In this study, we evaluated whether there is an interaction between FIR radiation and HO-1 in regulating vascular inflammation.

METHODS AND RESULTS: Treatment of cultured human umbilical vein endothelial cells (ECs) with FIR radiation stimulated HO-1 protein, mRNA, and promoter activity. HO-1 induction was dependent on the activation of the antioxidant responsive element/NF-E2-related factor-2 complex, and was likely a consequence of heat stress. FIR radiation also inhibited tumor necrosis factor (TNF)-alpha-mediated expression of E-selectin, vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, monocyte chemoattractant protein-1, interleukin-8, and the cytokine-mediated adhesion of monocytes to ECs. The antiinflammatory action of FIR was mimicked by bilirubin, and was reversed by the HO inhibitor, tin protoporphyrin-IX, or by the selective knockdown of HO-1. Finally, the antiinflammatory effect of FIR was also observed in patients undergoing hemodialysis.

CONCLUSIONS: These results demonstrate that FIR therapy exerts a potent antiinflammatory effect via the induction of HO-1. The ability of FIR therapy to inhibit inflammation may play a critical role in preserving blood flow and patency of AVFs in hemodialysis patients.

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Depression: 21st Century Solutions + The Dark Side of Wheat

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