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Abstract Title:

Ferulic acid potentiates the antibacterial activity of quinolone-based antibiotics against Acinetobacter baumannii.

Abstract Source:

Microb Pathog. 2019 Jan ;126:393-398. Epub 2018 Nov 23. PMID: 30476577

Abstract Author(s):

O B Ibitoye, T O Ajiboye

Article Affiliation:

O B Ibitoye

Abstract:

Ferulic acid is a cinnamic derivative of phenolic acid and its pharmacophore (catechol) is responsible for antioxidant, prooxidant and antibacterial activities. In this study, we evaluated the influence of ferulic acid on the antibacterial activity of quinolone-based antibiotics against Acinetobacter baumannii. The minimum inhibitory concentration of ferulic acid against Acinetobacter baumannii AB5075 were considerably lowered forΔsodB and ΔkatG mutants. Checkerboard assay shows synergistic interactions between ferulic acid and quinolones. In a murine sepsis model, ferulic acid potentiated the antibacterial activities of quinolones. Ferulic acid amplified quinolones-induced redox imbalance by increasing superoxide ion generation, NAD+/NADH ratio and ADP/ATP ratio. Conversely, the level of reduced glutathione was significantly lowered. We conclude that ferulic acid potentiates the antibacterial activity of quinolone-based antibiotics against A. baumannii by increasing ROS generation, energy metabolism and electron transport chain activity with a concomitant decrease in glutathione.

Study Type : In Vitro Study

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Sayer Ji
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