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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis ameliorated by folate supplement.

Abstract Source:

Rheumatol Int. 2010 Aug;30(10):1371-2. Epub 2009 Jul 12. PMID: 19597731

Abstract Author(s):

Jun-ichi Fukushi, Yasuharu Nakashima, Yukihide Iwamoto

Article Affiliation:

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Fukuoka, 812-8582, Japan. fukushi@med.kyushu-u.ac.jp

Abstract:

A 62-year-old male with a 10-year history of seropositive rheumatoid arthritis (RA) developed gynecomastia 8 months after beginning oral low-dose methotrexate (MTX) therapy. Two months after folate supplementation, the gynecomastia symptoms improved. Gynecomastia associated with low-dose MTX is a rare occurrence, with only nine cases previously reported in the literature. This is the first report showing folate supplementation to be effective against gynecomastia following low-dose MTX. Although it occurs infrequently, gynecomastia associated with low-dose MTX therapy should be considered in male patients with RA.

Study Type : Human: Case Report

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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