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Abstract Title:

Folic acid supplementation and cell kinetics of rectal mucosa in patients with ulcerative colitis.

Abstract Source:

Cancer Epidemiol Biomarkers Prev. 1997 Jun;6(6):469-71. PMID: 9184782

Abstract Author(s):

G Biasco, U Zannoni, G M Paganelli, R Santucci, P Gionchetti, G Rivolta, R Miniero, L Pironi, C Calabrese, G Di Febo, M Miglioli

Abstract:

It has been suggested that colon cancer risk in ulcerative colitis (UC) is correlated to a reduced bioavailability of folate. We studied the effects of folate supplementation on the pattern of rectal cell proliferation in patients affected by long-standing UC. In the rectal mucosa of these patients, an expansion of proliferating cells to the crypt surface is found frequently. This abnormality is considered an intermediate biomarker in chemoprevention trials. Twenty-four patients (13 males; age, 26-70 years; UC duration, 7-34 years) with UC in remission for 1 month at least were assigned randomly to one of the following treatments: (a) folinic acid (15 mg/day) or (b) placebo. Cell proliferation was analyzed through immunohistochemistry on sections of rectal biopsies incubated for 1 hour in a culture medium containing bromodeoxyuridine. Fragments were taken at admission to the study and after 3 months of treatment. As compared to the baseline values, after 3 months of therapy in patients treated with folinic acid, a significant reduction of the frequency of occurrence of labeled cells in the upper 40% of the crypts (phi h value) was observed (0.1836 +/- 0.0278 versus 0.1023 +/- 0.0255; P < 0.01). On the contrary, no significant proliferative changes were observed in the placebo group. These results suggest that folate supplementation contributes to regulating rectal cell proliferation in patients with long-standing UC. These findings may be significant for chemoprevention of colon cancer in these patients.

Study Type : Human Study

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Ulcerative Colitis



I ve just started taking Folic Acid [5-MTHF] and after 3 days my bleeding has decreased. Also my mood has improved greatly, something that nothing has helped thus far.

But, I ve experimented with sugar/Fructose intake in regular food, and that makes the bleeding so much worse. So now I dont eat wheat which does not create the problem of sugar cravings, and so I am able to resist the urge to eat sweets which in turn helps heal my UC. 

I will add some pancreatic enzymes to my regime of supplements and see if I can eliminate the problem myself.

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Sayer Ji
Founder of GreenMedInfo.com

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Easy Turmeric recipes + The Dark Side of Wheat

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