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Abstract Title:

Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation.

Abstract Source:

Phytother Res. 2014 Jan ;28(1):137-43. Epub 2013 Apr 12. PMID: 23580241

Abstract Author(s):

Mi-Ja Kim, Joseph Jeon, Jin-Sil Lee

Article Affiliation:

Mi-Ja Kim

Abstract:

This study examines the antiobesity effects of fucoidan in an animal model of diet-induced obesity. Mice were fed a standard diet or high-fat diet (HFD) for 5 weeks. After that, the mice were divided into four experimental groups, with 10 mice per group, including a standard diet group, HFD group, HFD containing 1% fucoidan (HFD + FUCO 1%) group and HFD containing 2% fucoidan (HFD + FUCO 2%) group. The fucoidan supplementation group had significantly decreased body-weight gain, food efficiency ratio and relative liver and epididymal fat mass compared with the HFD group. The mice supplemented with fucoidan showed significantly reduced triglyceride, total cholesterol and low-density lipoprotein levels in the plasma. Liver steatosis induced by the HFD improved in the fucoidan-supplemented group. Furthermore, fucoidan affected the down-regulation expression patterns of epididymal adipose tissue genes such as peroxisome proliferator-activated receptorγ, adipose-specific fatty acid binding protein and acetyl CoA carboxylase. Therefore, fucoidan may be considered for use in improving obesity.

Study Type : Animal Study

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