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Abstract Title:

Enhancement of gastric ulcer healing and angiogenesis by cochinchina Momordica seed extract in rats.

Abstract Source:

J Korean Med Sci. 2010 Jun;25(6):875-81. Epub 2010 May 24. PMID: 20514308

Abstract Author(s):

Jung Mook Kang, Nayoung Kim, Bongcheol Kim, Joo-Hyon Kim, Bong-Yong Lee, Ji Hyun Park, Mi Kyoung Lee, Hye Seung Lee, Joo Sung Kim, Hyun Chae Jung, In Sung Song

Article Affiliation:

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Abstract:

Cochinchina momordica seed is the dried ripe seed of Momordica cochinchinensis, a perennial vine. The antiulcer effect of an extract from cochinchina momordica seeds (SK-MS10) was evaluated in a rat model of acetic acid-induced gastric ulcers. Gastric ulcers were produced by subserosal injection of acetic acid. SK-MS10 (200 mg/kg) or vehicle was administered orally once per day for 14 days after the acetic acid injection. The stomach was removed and the ulcer size measured at day 7 and 14 of the treatment. Expression of vascular endothelial growth factor (VEGF) was assessed by real-time RT-PCR and Western blot analysis. In addition, the microvasculature density (MVD) adjacent to the ulcer margin was examined by immunohistochemistry. The treatment with SK-MS10 for 7 and 14 days significantly accelerated ulcer healing and increased the expression of mRNA (at day 7) as well as VEGF protein (at day 14) compared to the vehicle-treated rats. The MVD for factor VIII was also higher in the SK-MS10 treatment group compared to the vehicle-treated rats; however, these differences were not statistically significant. These results suggest that SK-MS10 treatment accelerates the healing of gastric ulcers via upregulation of VEGF and angiogenesis in an acetic acid rat model.

Study Type : Animal Study

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