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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Genipin Inhibits LPS-Induced Inflammatory Response in BV2 Microglial Cells.

Abstract Source:

Neurochem Res. 2017 Oct ;42(10):2769-2776. Epub 2017 May 11. PMID: 28497344

Abstract Author(s):

Jianjiao Wang, Liang Chen, Zuobin Liang, Yang Li, Fei Yuan, Jie Liu, Yu Tian, Zhen Hao, Fucheng Zhou, Xuanxi Liu, Yu Cao, Yongri Zheng, Qingsong Li

Article Affiliation:

Jianjiao Wang

Abstract:

Genipin, an aglycon of geniposide, has been reported to have anti-inflammatory effect. However, the anti-inflammatory activity of genipin on LPS-stimulated BV2 microglial cells has not been reported. In this study, we investigated the molecular mechanisms responsible for the anti-inflammatory activity of genipin both in vivo and in vitro. The levels of TNF-α, IL-1β, NO and PGEwere detected by ELISA. The expression of Nrf2, HO-1, and NF-κB were detected by western blot analysis. In vivo, genipin significantly attenuated LPS-induced memory deficit in the Morris water maze and passive avoidance tasks. Genipin also inhibited LPS-induced TNF-α and IL-1β expression in brain tissues. In vitro, our results showed that genipin inhibitedLPS-induced TNF-α, IL-1β, NO and PGEproduction in a concentration-dependent manner. Genipin also suppressed LPS-induced NF-κB activation. In addition, the expression of Nrf2 and HO-1 were up-regulated by treatment of genipin. Furthermore, the inhibition of genipin on inflammatory mediator production was attenuated by transfection with Nrf2 siRNA. In conclusion, genipin inhibited LPS-induced inflammatory response by activating Nrf2 signaling pathway in BV2 microglia.

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Depression: 21st Century Solutions + The Dark Side of Wheat

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