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Abstract Title:

Neuroprotective effect of ginger on anti-oxidant enzymes in streptozotocin-induced diabetic rats.

Abstract Source:

Food Chem Toxicol. 2010 Dec 22. Epub 2010 Dec 22. PMID: 21184796

Abstract Author(s):

Kondeti Ramudu Shanmugam, Korivi Mallikarjuna, Nishanth Kesireddy, Kesireddy Sathyavelu Reddy

Article Affiliation:

Division of Molecular Biology and Exercise Physiology, Department of Zoology, Sri Venkateswara University, Tirupati, AP 517 502, India; Department of Nutrition and Dietetics, Faculty of Allied and Health Sciences, University of Kebangsaan Malaysia, Jalan Raja Muda Aziz, 50300 Kuala Lumpur, Malaysia.

Abstract:

The aim of the present study was to investigate the effect of ginger on oxidative stress markers in the mitochondrial fractions of cerebral cortex (CC), cerebellum (CB), hippocampus (HC) and hypothalamus (HT) of diabetic rats. Diabetes exacerbates neuronal injury induced by hyperglycemia mediated oxidative damage. A marked decrease in anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione (GSH) and increase in malondialdehyde (MDA) was observed in the diabetic rats. Decreased activities of anti-oxidant enzymes in diabetic rats were augmented on oral administration of ginger. Moreover, ginger administration depleted the MDA level, which was earlier increased in the diabetic rats. These results suggest that ginger exhibit a neuroprotective effect by accelerating brain anti-oxidant defense mechanisms and down regulating the MDA levels to the normal levels in the diabetic rats. Thus, ginger may be used as therapeutic agent in preventing complications in diabetic patients.

Study Type : Animal Study

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