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Abstract Title:

Ginsenoside Re Ameliorates Brain Insulin Resistance and Cognitive Dysfunction in High-fat Diet-induced C57BL/6 Mice.

Abstract Source:

J Agric Food Chem. 2017 Mar 17. Epub 2017 Mar 17. PMID: 28314104

Abstract Author(s):

Jong Min Kim, Chang Hyeon Park, Seon Kyeong Park, Tae Wan Seung, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Dae Ok Kim, Ho Jin Heo

Article Affiliation:

Jong Min Kim

Abstract:

The ameliorating effects of ginsenoside Re (G Re) on high-fat diet (HFD)-induced insulin resistance in C57BL/6 mice were investigated to assess its physiological function. In the results of behavioral tests, G Re improved cognitive dysfunction on diabetic mice using Y-maze, passive avoidance and Morris water maze tests. G Re also significantly recovered hyperglycemia and fasting blood glucose level. In the results of serum analysis, G Re decreased triglyceride (TG), total cholesterol (TCHO), low density lipoprotein cholesterol (LDLC), glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT), and increased the ratio of high density lipoprotein cholesterol (HDLC). G Re regulated the acetylcholine (ACh), acetylcholinesterase (AChE), malondialdehyde (MDA), superoxide dismutase (SOD) and oxidized glutathione (GSH)/total GSH by regulating the c-Jun N-terminal protein kinase (JNK) pathway. These findings suggest that G Re could be used to improve HFD-induced insulin resistance condition by ameliorating hyperglycemia via protecting the cholinergic and antioxidant system in the mice brains.

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Sayer Ji
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