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Article Publish Status: FREE
Abstract Title:

Global analysis of ginsenoside Rg1 protective effects inβ-amyloid-treated neuronal cells.

Abstract Source:

J Ginseng Res. 2017 Oct ;41(4):566-571. Epub 2016 Dec 8. PMID: 29021705

Abstract Author(s):

Ji Seon Shim, Min-Young Song, Sung-Vin Yim, Seung-Eun Lee, Kang-Sik Park

Article Affiliation:

Ji Seon Shim

Abstract:

BACKGROUND: A number of reports have described the protective effects of ginsenoside Rg1 (Rg1) in Alzheimer's disease (AD). However, the protective mechanisms of Rg1 in AD remain elusive.

METHODS: To investigate the potential mechanisms of Rg1 inβ-amyloid peptide-treated SH-SY5Y cells, a comparative proteomic analysis was performed using stable isotope labeling with amino acids in cell culture combined with nano-LC-MS/MS.

RESULTS: We identified a total of 1,149 proteins in three independent experiments. Forty-nine proteins were significantly altered by Rg1 after exposure of the cells toβ-amyloid peptides. The protein interaction network analysis showed that these altered proteins were clustered in ribosomal proteins, mitochondria, the actin cytoskeleton, and splicing proteins. Among these proteins, mitochondrial proteins containing HSD17B10, AARS2, TOMM40, VDAC1, COX5A, and NDUFA4 were associated with mitochondrial dysfunction in the pathogenesis of AD.

CONCLUSION: Our results suggest that mitochondrial proteins may be related to the protective mechanisms of Rg1 in AD.

Study Type : In Vitro Study

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