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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Gluten-sensitive enteropathy in a cynomolgus monkey.

Abstract Source:

Lab Anim Sci. 1988 Oct ;38(5):592-4. PMID: 3193752

Abstract Author(s):

J D Wagner, C P Jerome, M R Adams

Article Affiliation:

Department of Comparative Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.

Abstract:

A malabsorption syndrome was observed in a cynomolgus macaque. Clinical signs included weight loss despite increased appetite, and diarrhea, characterized by an increased volume of soft, tan, malodorous feces. Clinicopathologic findings included hypoalbuminemia, generalized dilation of bowel loops with a prolonged transit time, steatorrhea and markedly diminished absorption of D-xylose. Biopsies of the duodenum and jejunum had total villous atrophy, crypt hyperplasia and a plasmacytic-lymphocytic infiltrate of the lamina propria. The monkey's diet was changed to a semi-synthetic diet containing no grain products. Subsequently, stool characteristics, body weight and intestinal villous morphology returned to normal. This response to removal of grain products from the diet suggests a syndrome similar to gluten-sensitivity enteropathy in human beings.

Study Type : Animal Study
Additional Links
Problem Substances : Gluten : CK(1088) : AC(167)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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