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Abstract Title:

Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.

Abstract Source:

J Neurooncol. 2013 Mar ;112(1):39-48. Epub 2013 Feb 8. PMID: 23392846

Abstract Author(s):

Huailei Liu, Dayong Han, Yaohua Liu, Xu Hou, Jianing Wu, Huadong Li, Jie Yang, Chen Shen, Guang Yang, Changyu Fu, Xianfeng Li, Hui Che, Jing Ai, Shiguang Zhao

Article Affiliation:

Huailei Liu

Abstract:

Harmine hydrochloride (Har-hc), a derivative from Harmine which is a natural extractive from plants, has been considered for treatment of kinds of cancers and cerebral diseases. In this study, we found that Har-hc clearly decreased cell viability, induced apoptosis and inhibited Akt phosphorylation in glioblastoma cell lines. Moreover, Har-hc had the ability to inhibit self-renewal and promote differentiation of glioblastoma stem like cells (GSLCs) accompanied by inhibition of Akt phosphorylation. Especially, we demonstrated that Har-hc inhibited neurosphere formation of human primary GSLCs. In vivo test also confirmed Har-hc decreased the tumorigenicity of GSLCs. Thus we conclude that Har-hc has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. Administration of Har-hc may act as a new approach to glioblastoma treatment.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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