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Article Publish Status: FREE
Abstract Title:

Oral Administration of p-Hydroxycinnamic Acid Attenuates Atopic Dermatitis by Downregulating Th1 and Th2 Cytokine Production and Keratinocyte Activation.

Abstract Source:

PLoS One. 2016 ;11(3):e0150952. Epub 2016 Mar 9. PMID: 26959360

Abstract Author(s):

Hyun-Su Lee, Eun-Ju Choi, Kyung-Sik Lee, Hye-Ran Kim, Bo-Ra Na, Min-Sung Kwon, Gil-Saeng Jeong, Hyun Gyu Choi, Eun Young Choi, Chang-Duk Jun

Article Affiliation:

Hyun-Su Lee

Abstract:

Atopic dermatitis (AD) is a complex disease that is caused by various factors, including environmental change, genetic defects, and immune imbalance. We previously showed that p-hydroxycinnamic acid (HCA) isolated from the roots of Curcuma longa inhibits T-cell activation without inducing cell death. Here, we demonstrated that oral administration of HCA in a mouse model of ear AD attenuates the following local and systemic AD manifestations: ear thickening, immune-cell infiltration, production of AD-promoting immunoregulatory cytokines in ear tissues, increased spleen and draining lymph node size and weight, increased pro-inflammatory cytokine production by draining lymph nodes, and elevated serum immunoglobulin production. HCA treatment of CD4+ T cells in vitro suppressed their proliferation and differentiation into Th1 or Th2 and their Th1 and Th2 cytokine production. HCA treatment of keratinocytes lowered their production of the pro-inflammatory cytokines that drive either Th1 or Th2 responses in AD. Thus, HCA may be of therapeutic potential for AD as it acts by suppressing keratinocyte activation and downregulating T-cell differentiation and cytokine production.

Study Type : Animal Study

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