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Abstract Title:

Incidence of small bowel injury induced by low-dose aspirin: a crossover study using capsule endoscopy in healthy volunteers.

Abstract Source:

Digestion. 2009;79(1):44-51. Epub 2009 Feb 26. PMID: 19246922

Abstract Author(s):

Hiroki Endo, Kunihiro Hosono, Masahiko Inamori, Shingo Kato, Yuichi Nozaki, Kyoko Yoneda, Tomoyuki Akiyama, Koji Fujita, Hirokazu Takahashi, Masato Yoneda, Yasunobu Abe, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Kensuke Kubota, Satoru Saito, Nobuyuki Matsuhashi, Atsushi Nakajima

Article Affiliation:

Division of Gastroenterology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Japan. t066011b@yokohama-cu.ac.jp

Abstract:

BACKGROUND AND AIMS: Small intestinal toxicity of low-dose aspirin remains unclear. The purpose of this capsule endoscopy study was to assess the incidence of small bowel injury in healthy volunteers treated with short-term low-dose aspirin.

METHODS: Healthy subjects were randomly assigned to receive low-dose aspirin for 14 days (Aspirin group) or no drugs for 14 days (Control group). The two treatment occasions were separated by a washout period of at least 4 weeks. All subjects underwent capsule endoscopy at the end of each treatment period.

RESULTS: After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023). The incidence of small bowel mucosal breaks in the Aspirin group was higher than that in the Control group, although the difference was not significant (30 vs. 0%; p = 0.210).

CONCLUSIONS: This is the first pilot study using capsule endoscopy to report on the relation between small bowel injury and low-dose aspirin. Among the healthy subjects, the short-term administration of low-dose aspirin was associated with a mild mucosal inflammation of the small bowel.

Study Type : Human Study
Additional Links
Problem Substances : Aspirin : CK(504) : AC(72)

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Sayer Ji
Founder of GreenMedInfo.com

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