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Article Publish Status: FREE
Abstract Title:

The In Vitro Impact of the Herbicide Roundup on Human Sperm Motility and Sperm Mitochondria.

Abstract Source:

Toxics. 2017 Dec 21 ;6(1). Epub 2017 Dec 21. PMID: 29267194

Abstract Author(s):

George Anifandis, George Amiridis, Konstantinos Dafopoulos, Alexandros Daponte, Eleni Dovolou, Eleftherios Gavriil, Vyron Gorgogietas, Elli Kachpani, Zissis Mamuris, Christina I Messini, Katerina Vassiou, Anna-Maria G Psarra

Article Affiliation:

George Anifandis

Abstract:

Toxicants, such as herbicides, have been hypothesized to affect sperm parameters. The most common method of exposure to herbicides is through spraying or diet. The aim of the present study was to investigate the effect of direct exposure of sperm to 1 mg/L of the herbicide Roundup on sperm motility and mitochondrial integrity. Sperm samples from 66 healthy men who were seeking semen analysis were investigated after written informed consent was taken. Semen analysis was performed according to the World Health Organization guidelines (WHO, 2010). Mitochondrial integrity was assessed through mitochondrial staining using a mitochondria-specific dye, which is exclusively incorporated into functionally active mitochondria. A quantity of 1 mg/L of Roundup was found to exert a deleterious effect on sperm's progressive motility, after 1 h of incubation (mean difference between treated and control samples = 11.2%) in comparison with the effect after three hours of incubation (mean difference = 6.33%, p<0.05), while the relative incorporation of the mitochondrial dye in mitochondria of the mid-piece region of Roundup-treated spermatozoa was significantly reduced compared to relative controls at the first hour of incubation, indicating mitochondrial dysfunction by Roundup. Our results indicate that the direct exposure of semen samples to the active constituent of the herbicide Roundup at the relatively low concentration of 1 mg/L has adverse effects on sperm motility, and this may be related to the observed reduction in mitochondrial staining.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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