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Abstract Title:

Ethyl acetate fraction from Hibiscus sabdariffa L. attenuates diabetes-associated cognitive impairment in mice.

Abstract Source:

Food Res Int. 2018 Mar ;105:589-598. Epub 2017 Nov 26. PMID: 29433251

Abstract Author(s):

Tae Wan Seung, Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Sang Hyun Park, Bong Seok Kwon, Chang Jun Lee, Jeong Eun Kang, Dae Ok Kim, Uk Lee, Ho Jin Heo

Article Affiliation:

Tae Wan Seung

Abstract:

The ameliorating effects of the ethyl acetate fraction from Hibiscus sabdariffa L. (EFHS)against diabetes mellitus (DM)and DM-induced cognitive impairment were investigated on streptozotocin (STZ)-induced DM mice. The EFHS groups showed improved hyperglycemia and glucose tolerance compared to the STZ group. Furthermore, their liver and kidney function and lipid metabolic imbalance in the blood serum were effectively recovered. The EFHS groups significantly ameliorated STZ-induced cognitive impairment in Y-maze, passive avoidance, and Morris water maze (MWM)tests. The EFHS groups showed significant improvement in the antioxidant and cholinergic systems of the brain tissue. In addition, EFHS had an excellent ameliorating effect on protein expression levels from the tau hyperphosphorylation pathways, such as phospho-c-Jun N-terminal kinases (p-JNK),phospho-tau (p-tau),and cleaved poly (ADP-ribose) polymerase (c-PARP).The main compounds of EFHS were identified as various phenolic compounds, including hibiscus acid, caffeoylquinic acid (CQA)isomers, and quercetin derivates. Therefore, EFHS containing various physiologically active materials can potentially be used for improving DM-induced cognitive impairment via its antioxidant activity, improvement of the cholinergic system, and hyperphosphorylation tau signaling.

Study Type : Animal Study

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