Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence in colon cancer patients. - GreenMedInfo Summary
Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance).
PLoS One. 2014 ;9(6):e99816. Epub 2014 Jun 17. PMID: 24937507
Michael A Fuchs
BACKGROUND: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown.
METHODS: We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models.
RESULTS: Patients consuming≥ 2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04-2.68), compared with those consuming<2 servings per month (P(trend) = 0.02). The association of sugar-sweetened beverages on cancer recurrence or mortality appeared greater among patients who were both overweight (body mass index≥ 2 5 kg/m(2)) and less physically active (metabolic equivalent task-hours per week<18) (HR = 2.22; 95% CI, 1.29-3.81, P(trend) = 0.0025).
CONCLUSION: Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence and mortality in stage III colon cancer patients.