Honey and a glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat. - GreenMedInfo Summary

Abstract Title:

Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.

Abstract Source:

Exp Toxicol Pathol. 2002 Nov;54(3):217-21. PMID: 12484559

Abstract Author(s):

Kamel Gharzouli, Smain Amira, Akila Gharzouli, Seddik Khennouf

Article Affiliation:

kam_gharzouli@hotmail.com

Abstract:

The gastric cytoprotective properties of natural honey (monofloral and polyfloral specimens) and of a glucose-fructose-sucrose-maltose mixture (GFSM) was evaluated in the rat using absolute ethanol, indomethacin and acidified acetylsalicylic acid (ASA-HCl) as necrotising agents. Prior gastric administration of honey (2.5 g/kg) to animals induced a net reduction of hemorrhagic lesions length of the mucosa. Protection of the stomach elicited by both types of honey and GFSM was almost total against ethanol-induced lesions. Similar results were also observed when using ASA-HCl except that the percent protection was 87%. The percent reduction of indomethacin-induced gastric lesions was variable according to the nature of the test solution: GFSM mixture (41.1%)

Article Published Date : Nov 01, 2002
Study Type : Animal Study
Additional Links
Substances : Fructose : CK(4) : AC(2), Glucose : CK(12) : AC(2), Honey : CK(251) : AC(50), Maltose : CK(2) : AC(1), Sucrose : CK(12) : AC(2)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)
Additional Keywords : Drug: Indomethacin : CK(30) : AC(17)

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