Hops contains a compound, demethylxanthohumol, which induces programmed cell death in Burktt lymphoma and acute lymphoblastic leukemia (ALL) cell lines. - GreenMedInfo Summary

Abstract Title:

Synthesis of demethylxanthohumol, a new potent apoptosis-inducing agent from hops.

Abstract Source:

Chem Biodivers. 2005 Oct;2(10):1331-7. PMID: 17191934

Abstract Author(s):

Reinhard A Diller, Herbert M Riepl, Oliver Rose, Corazon Frias, Günter Henze, Aram Prokop

Abstract:

Starting from commercially available phloracetophenone (= 1-(2,4,6-trihydroxyphenyl)ethanone), we synthesized demethylxanthohumol (4), a derivative of xanthohumol, devoid of 6'-O-methyl group. Both are prenylchalcones derived from hops (Humulus lupulus). The synthesis was accomplished by an aldol condensation between MOM-protected acetophenone 2 and MOM-protected benzaldehyde 3. The resulting demethylxanthohumol (4) displayed antiproliferative properties. Demethylxanthohumol (4) induced also apoptosis via the mitochondrial pathway in BJAB cells (Burkitt lymphoma cell line) and in primary lymphoblasts of childhood acute lymphoblastic leukemia (ALL).

Article Published Date : Oct 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Hops : CK(51) : AC(20)
Diseases : Acute lymphoblastic leukemia (ALL) : CK(96) : AC(29), Burkitt Lymphoma : CK(10) : AC(9), Lymphoma : CK(209) : AC(69)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

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