Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia.

Abstract Source:

Biol Pharm Bull. 2004 Nov;27(11):1844-9. PMID: 18565502

Abstract Author(s):

Hai Yan Zhang, Chun Yan Zheng, Han Yan, Zhi Fei Wang, Li Li Tang, Xin Gao, Xi Can Tang

Abstract:

Huperzine A (HupA), a novel Lycopodium alkaloid isolated from Chinese folk medicine Huperzia serrata (Qian Ceng Ta), is a potent, selective and well-tolerated inhibitor of acetylcholinesterase (AChE). It has been proven to significantly improve the learning and memory impairment in Alzheimer's disease (AD) and vascular dementia (VaD) patients in China. Interestingly, our recent data indicate that HupA also possesses other protective functions. This paper will give an overview on the protective effects of HupA, which includes regulating beta-amyloid precursor protein (APP) metabolism, protecting against Abeta-mediated oxidative stress, apoptosis and mitochondrial dysfunction, as well as anti-inflammation. The multiple neuroprotective effects of HupA might yield additional beneficial effects in AD and VaD therapy.

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Sayer Ji
Founder of GreenMedInfo.com

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Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

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