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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide.

Abstract Source:

Free Radic Biol Med. 2009 Jun 1;46(11):1454-62. Epub 2009 Mar 9. PMID: 19272446

Abstract Author(s):

Xin Gao, Chun Yan Zheng, Ling Yang, Xi Can Tang, Hai Yan Zhang

Abstract:

Our previous work in cells and animals showed that mitochondria are involved in the neuroprotective effect of huperzine A (HupA). In this study, the effects of HupA on isolated rat brain mitochondria were investigated. In addition to inhibiting the Abeta(25-35) (40 microM)-induced decrease in mitochondrial respiration, adenosine 5'-triphosphate (ATP) synthesis, enzyme activity, and transmembrane potential, HupA (0.01 or 0.1 microM) effectively prevented Abeta-induced mitochondrial swelling, reactive oxygen species increase, and cytochrome c release. More interestingly, administration of HupA to isolated mitochondria promoted the rate of ATP production and blocked mitochondrial swelling caused by normal osmosis. These results indicate that HupA protects mitochondria against Abeta at least in part by preserving membrane integrity and improving energy metabolism. These direct effects on mitochondria further extend the noncholinergic functions of HupA.

Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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