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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Hyperbaric oxygen treatment suppresses withdrawal signs in morphine-dependent mice.

Abstract Source:

Brain Res. 2016 Aug 14. Epub 2016 Aug 14. PMID: 27534375

Abstract Author(s):

Daniel Nicoara, Yangmiao Zhang, Jordan T Nelson, Abigail L Brewer, Prianka Maharaj, Shea N DeWald, Donald Y Shirachi, Raymond M Quock

Article Affiliation:

Daniel Nicoara

Abstract:

Hyperbaric oxygen (HBO2) therapy reportedly reduces opiate withdrawal in human subjects. The purpose of this research was to determine whether HBO2 treatment could suppress physical signs of withdrawal in opiate-dependent mice. Male NIH Swiss mice were injected s.c. with morphine sulfate twice a day for 4 days, the daily dose gradually increasing from 50mg/kg on day 1 to 125mg/kg on day 4. On day 5, withdrawal was precipitated by i.p. injection of 5.0mg/kg naloxone. Mice were observed for physical withdrawal signs, including jumping, forepaw tremor, wet-dog shakes, rearing and defecation for 30min. Sixty min prior to the naloxone injection, different groups of mice received either a 30-min or 60-min HBO2 treatment at 3.5 atm absolute. HBO2 treatment significantly reduced naloxone-precipitated jumping, forepaw tremor, wet-dog shakes, rearing and defecation. Based on these experimental findings, we concluded that treatment with HBO2 can suppress physical signs of withdrawal syndrome in morphine-dependent mice.

Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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