Sayer Ji
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Abstract Title:

Hypericin lights up the way for the potential treatment of nasopharyngeal cancer by photodynamic therapy.

Abstract Source:

Curr Clin Pharmacol. 2006 Sep;1(3):217-22. PMID: 18666746

Abstract Author(s):

Malini Olivo, Hong-Yan Du, Boon-Huat Bay

Abstract:

Photodynamic therapy (PDT) involves the administration of a photosensitizer followed by light irradiation with a specific wavelength, giving rise to irreversible tissue destruction. Hypericin, a herbal extract derived from Hypericum perforatum or St. John's Wort, has minimal toxicity but exhibits potent photo-damaging effects in the presence of light. Hypericin is known to generate a high yield of singlet oxygen and other reactive oxygen species that are associated with photo-oxidative cellular damage. The application of PDT with hypericin for the treatment of cancers such as recurrent mesothelioma and skin cancer has been validated in clinical trials. This mini-review focuses on the investigative studies of hypericin as a potential photodynamic agent in the treatment of nasopharyngeal cancer (NPC) in in vitro and in vivo models. NPC is an enigmatic tumor with a multifactorial etiology and a high incidence in the populations of Southern China.

 
 

Study Type : Commentary

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Sayer Ji
Founder of GreenMedInfo.com

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Easy Turmeric recipes + The Dark Side of Wheat

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