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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, andα-glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study.

Abstract Source:

J Biochem Mol Toxicol. 2017 Dec ;31(12). Epub 2017 Sep 13. PMID: 28902458

Abstract Author(s):

Parham Taslimi, Cuneyt Caglayan, İlhami Gulcin

Article Affiliation:

Parham Taslimi

Abstract:

Natural products from food and plant sources have been used for medicinal usage for ages. Also, natural products with therapeutic significance are compounds derived from animals, plants, or any microorganism. In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II),α-glucosidase (α-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). These phenolic compounds were tested for the inhibition of α-glycosidase, hCA I, hCA II, AChE, and BChE enzymes and demonstrated efficient inhibition profiles with Kvalues in the range of 3.70 ± 0.92-79.66 ± 20.81 nM against hCA I, 2.98 ± 0.33-84.88 ± 40.32 nM against hCA II, 4.93 ± 2.01-593.60 ± 134.74 nM against α-Gly, 0.52 ± 0.18-46.80 ± 17.15 nM against AChE, and 1.25 ± 0.22-32.08 ± 2.68 against BChE.

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Depression: 21st Century Solutions + The Dark Side of Wheat

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