Individuals with untreated celiac disease may have reduced bone mineral density associated with deficiencies of nutrients. - GreenMedInfo Summary

Abstract Title:

Metabolic osteopathy in celiac disease: importance of a gluten-free diet.

Abstract Source:

Nutr Rev. 2009 Oct;67(10):599-606. PMID: 19785691

Abstract Author(s):

Vanessa D Capriles, Ligia A Martini, José Alfredo G Arêas

Article Affiliation:

Nutrition Department, School of Public Health, São Paulo University, São Paulo, Brazil.

Abstract:

Reduced bone mineral density (BMD) is frequently found in individuals with untreated celiac disease (CD), possibly due to calcium and vitamin D malabsorption, release of pro-inflammatory cytokines, and misbalanced bone remodeling. A gluten-free diet (GFD) promotes a rapid increase in BMD that leads to complete recovery of bone mineralization in children. Children may attain normal peak bone mass if the diagnosis is made and treatment is given before puberty, thereby preventing osteoporosis in later life. A GFD improves, but rarely normalizes, BMD in patients diagnosed with CD in adulthood. In some cases, nutritional supplementation may be necessary. More information on therapeutic alternatives is needed.

Article Published Date : Oct 01, 2009
Study Type : Review
Additional Links
Substances : Calcium : CK(232) : AC(35), Vitamin D : CK(1682) : AC(238)
Diseases : Celiac Disease : CK(1527) : AC(215), Celiac Disease: In Children and Adolescents : CK(32) : AC(5), Celiac Disease: Refractory : CK(11) : AC(3), Inflammation : CK(1077) : AC(363), Osteoporosis : CK(1171) : AC(205), Osteoporosis: In Children & Adolescents : CK(2) : AC(2)
Therapeutic Actions : Dietary Modification: Wheat/Gluten Free : CK(259) : AC(29)

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