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Abstract Title:

Inflammatory Inhibitory Activity of Sesquiterpenoids from Atractylodes macrocephala Rhizomes.

Abstract Source:

Chem Pharm Bull (Tokyo). 2016 ;64(5):507-11. PMID: 27150484

Abstract Author(s):

Le Son Hoang, Manh Hung Tran, Joo-Sang Lee, Quynh Mai Thi Ngo, Mi Hee Woo, Byung Sun Min

Article Affiliation:

Le Son Hoang

Abstract:

Three new sesquiterpenoids, 13-hydroxyl-atractylenolide II (1), 4-ketone-atractylenolide III (2), and eudesm-4(15)-ene-7β,11-diol (3), along with eleven known compounds (4-14), were isolated from the rhizomes of Atractylodes macrocephala. The structures and relative configurations of 1-3 were determined by analysis of the spectroscopic data, and the absolute configurations of 1 and 2 were assigned by circular dichroism technique. The anti-inflammatory activities of these isolates were evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cells; compounds 4, 7, and 8 exhibited moderate efficacy with IC50 values of 48.6±0.5, 46.4±3.2, and 32.3±2.9 µM, respectively.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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