Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Anti-arthritic and disease modifying activity of Terminalia chebula Retz. in experimental models.

Abstract Source:

J Pharm Pharmacol. 2010 Dec;62(12):1801-6. Epub 2010 Oct 4. PMID: 21054408

Abstract Author(s):

Vinod Nair, Surender Singh, Yogendra Kumar Gupta

Article Affiliation:

Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.

Abstract:

OBJECTIVE: This study evaluates the anti-arthritic effect of Terminalia chebula hydroalcoholic extract (TCHE) in experimental models and attempts to correlate the effect of treatment on macrophage-derived pro-inflammatory cytokine expression and extent of disease activity.

METHODS: Arthritis was induced in rats by subplantar administration of either formaldehyde or complete Freund's adjuvant (CFA). Joint size was measured at regular intervals by using a micrometer screw gauge. Serum and ankle joints of rats immunized with CFA were collected and subjected to ELISA for estimation of TNF-α level and immuno-histochemistry for detection of IL-1β, IL-6 and TNF-R1, respectively. An acute and 28-day oral toxicity study was carried out to evaluate the safety of the test drug.

KEY FINDINGS: TCHE produced a significant inhibition of joint swelling as compared with control in both formaldehyde-induced and CFA-induced arthritis. TCHE treatment also reduced serum TNF-α level and synovial expression of TNF-R1, IL-6 and IL-1β. Results of acute toxicity study showed that the oral LD50 of TCHE was>2000 mg/kg. Chronic administration also did not produce any significant physiological changes as compared with normal rats.

CONCLUSION: Results indicate that the anti-arthritic activity of TCHE was at least in part due to its modulatory effect on pro-inflammatory cytokine expression in the synovium. We believe that TCHE has the potential to be used as a disease-modifying agent in treatment of rheumatoid arthritis.

Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Inflammatory : CK(298) : AC(83)

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.