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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Positive patch-test reactions to iodopropynyl butylcarbamate: retrospective analysis of North American contact dermatitis group data, from 1998 to 2008.

Abstract Source:

Dermatitis. 2010 Dec;21(6):303-10. PMID: 21144341

Abstract Author(s):

Erin M Warshaw, Dilangani Boralessa Ratnayake, Howard I Maibach, Denis Sasseville, Donald V Belsito, Kathryn A Zug, Joseph F Fowler, James S Taylor, C G Toby Mathias, Anthony F Fransway, Vincent A Deleo, James G Marks, Frances J Storrs, Melanie D Pratt, Robert L Rietschel

Abstract:

BACKGROUND: iodopropynyl butylcarbamate (IPBC), a commonly used preservative, is found in industrial and personal care products.

OBJECTIVE: to evaluate prevalence, clinical relevance, occupational relationship, and sources of positive reactions to IPBC in patients in North America.

METHODS: the North American Contact Dermatitis Group (NACDG) tested IPBC 0.1% and/or 0.5% in petrolatum (pet) between 1998 and 2008. Two patient groups of interest were defined, based on patch-test reactions to IPBC: weak (+) reactors and strong (++ or +++) reactors. Patient characteristics, site(s) of dermatitis, sources of positive reactions, clinical relevance, and occupational relevance to IPBC were tabulated.

RESULTS: of the 25,321 patients tested, there were 226 (0.9%) weak reactors and 67 (0.3%) strong reactors. For IPBC-positive patients, the most frequent sites of dermatitis were scattered generalized distribution, hands, and arms. The majority (>50%) of currently relevant reactions were to personal care products, and most reactions (>90%) were not related to occupation. Only four of the strong reactors had definite clinical relevance (positive use-test reaction or positive patch-test reaction to a product containing IPBC). The frequency of positive reactions increased (0.2% vs 1.5%) when the higher concentration of IPBC was utilized, but most (>64%) were weak reactions, of which some were likely irritant.

CONCLUSIONS: allergy to IPBC is relatively uncommon. When clinically relevant, personal care products were the most likely allergen source. Because IPBC is a marginal irritant, caution should be utilized when testing with higher concentrations of IPBC (≥ 0.5% pet) and when interpreting weak (+) reactions. Verification of clinical relevance by use test or repeat patch testing or both is also important.

Study Type : Human Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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