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Abstract Title:

Bisphenol A Exposure Impairs Epididymal Development during the Peripubertal Period of Rats: Inflammatory Profile and Tissue Changes.

Abstract Source:

Basic Clin Pharmacol Toxicol. 2017 Aug 30. Epub 2017 Aug 30. PMID: 28857484

Abstract Author(s):

Fernanda Mithie Ogo, Glaucia Eloisa Munhoz de Lion Siervo, Larissa Staurengo-Ferrari, Leonardo de Oliveira Mendes, Nicla Renata Luchetta, Henrique Rodrigues Vieira, Victor Fattori, Waldiceu Aparecido Verri, Wellerson Rodrigo Scarano, Glaura Scantamburlo Alves Fernandes

Article Affiliation:

Fernanda Mithie Ogo

Abstract:

Bisphenol A (BPA) is a synthetic non-steroidal oestrogen used in the production of plastics. BPA can cause alterations in the endocrine system of humans and animals at varied stages of development. During puberty, altered morphological, sexual behaviour and completion of the epididymal development occurs. Therefore, this study aimed to evaluate the effects of BPA on epididymal development during the peripubertal period of rats. Male Wistar rats were treated with BPA via gavage at doses of 20μg/kg or 200 μg/kg/day (postnatal day (PND) 36-66). The control group received the vehicles under the same conditions. Feed and water were provided ad libitum. On PND 67, the epididymis was removed, weighed, divided into caput/corpus and cauda sections. It was then used for: sperm count determination; histopathological and stereological evaluation; inflammatory cell enzymatic profiling (myeloperoxidase activity-MPO; N-acetylglucosaminidase-NAG); immunohistochemistry for IL-6; and evaluation of superoxide anion levels and malondialdehyde-MDA. Exposure to BPA at 200 μg/kg caused a significantincrease of MPO activity and immunoreactivity to IL-6 (Interleukin 6) as well as remodelling of tissue components in the caput/corpus and cauda regions of the epididymis. Under these experimental conditions, it is concluded that BPA alters postnatal epididymal development. This article is protectedby copyright. All rights reserved.

Study Type : Animal Study
Additional Links
Problem Substances : Bisphenol A : CK(685) : AC(178)

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Sayer Ji
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