n/a
Article Publish Status: FREE
Abstract Title:

Down-Regulation of Hepatic de novo Lipogenesis and Adipogenesis in Adipocytes by Pinus densiflora Bark Extract.

Abstract Source:

J Microbiol Biotechnol. 2017 Sep 5. Epub 2017 Sep 5. PMID: 28870006

Abstract Author(s):

Hyemyoung Ahn, Jeongho Jeong, Knowledge Mudhibadi Moyo, Yungsun Ryu, Bokkee Min, Seong Ho Yun, Hwa Yeon Kim, Wooki Kim, Gwang Woong Go

Article Affiliation:

Hyemyoung Ahn

Abstract:

Korean red pine (Pinus densiflora) bark extract, PineXol (PX), was investigated on its potential anti-oxidant and anti-inflammation effects in vitro. It was hypothesized that PX treatment (25-150µg/mL) would reduce the lipid synthesis in HepG2 hepatocytes as well as lipid accumulation in 3T3-L1 adipocytes. Hepatocytes' intracellular triglycerides and cholesterol were decreased in the PX 150 µg/mL treatment group compared to the control (p<0.05). Consequently, de novo lipogenic proteins; acetyl-CoA carboxylase 1, stearoyl-CoA desaturase 1, elongase of very long chain fatty acids 6, glycerol-3-phosphate acyltransferase 1, and sterol regulatory element-binding protein 1, were significantly decreased in hepatocytes by PX 150µg/mL treatment compared to the control (p<0.05). In the differentiated 3T3-L1 adipocytes, the lipid accumulation was significantly attenuated by all PX treatments (p<0.01). Regulators of adipogenesis including CCAAT-enhancer-binding proteins alpha, peroxisome proliferator-activated receptor gamma and perilipin were decreased in PX 100µg/mL treatment compared to the control (p<0.05). In conclusion, PX might have anti-obese effects by blocking hepatic lipogenesis and by inhibiting adipogenesis in adipocytes.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.