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Abstract Title:

Lactobacillus plantarum CCFM639 Alleviate Trace Element Imbalance-Related Oxidative Stress in Liver and Kidney of Chronic Aluminum Exposure Mice.

Abstract Source:

Biol Trace Elem Res. 2016 Sep 14. Epub 2016 Sep 14. PMID: 27627960

Abstract Author(s):

Leilei Yu, Qixiao Zhai, Ruijie Yin, Peng Li, Fengwei Tian, Xiaoming Liu, Jianxin Zhao, Jianhua Gong, Hao Zhang, Wei Chen

Article Affiliation:

Leilei Yu

Abstract:

Aluminum (Al) has various adverse effects on health of humans and animals. The aim of present study was to demonstrate that Lactobacillus plantarum CCFM639 can alleviate the adverse effects on liver and kidney of mice caused by chronic Al exposure. Animals were assigned into control, CCFM639 only, Al only, Al plus CCFM639, and Al plus deferiprone groups. The strain was given by oral gavage for 14 weeks, and Al was introduced via drinking water for the first 8 weeks. Analyses of Al and trace elements levels in feces, blood, and tissues were performed. The biochemical markers (GSH, GPx, SOD, CAT, and MDA) of oxidative stress in livers and kidneys, as well as the levels of ALT, AST, BUN, andCRE in blood, were determined. Our results showed that L. plantarum CCFM639 can significantly reduce Al accumulation in tissues, regulate imbalance of trace elements, and thereby alleviate oxidative stress and pathological changes in hepatic and renal tissues. Therefore, L. plantarum CCFM639 couldalleviate Al-induced hepatic and renal injuries, and the possible mechanisms may involve in regulating the imbalance of trace elements.

Study Type : Animal Study

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