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Abstract Title:

Lectin of Abelmoschus esculentus (okra) promotes selective antitumor effects in human breast cancer cells.

Abstract Source:

Biotechnol Lett. 2014 Mar ;36(3):461-9. Epub 2013 Oct 16. PMID: 24129958

Abstract Author(s):

Leonardo G Monte, Tatiane Santi-Gadelha, Larissa B Reis, Elizandra Braganhol, Rafael F Prietsch, Odir A Dellagostin, Rodrigo Rodrigues E Lacerda, Carlos A A Gadelha, Fabricio R Conceição, Luciano S Pinto

Article Affiliation:

Leonardo G Monte

Abstract:

The anti-tumor effects of a newly-discovered lectin, isolated from okra, Abelmoschus esculentus (AEL), were investigated in human breast cancer (MCF7) and skin fibroblast (CCD-1059 sk) cells. AEL induced significant cell growth inhibition (63 %) in MCF7 cells. The expression of pro-apoptotic caspase-3, caspase-9, and p21 genes was increased in MCF7 cells treated with AEL, compared to those treated with controls. In addition, AEL treatment increased the Bax/Bcl-2 ratio in MCF7 cells. Flow cytometry also indicated that cell death (72 %) predominantly occurred through apoptosis. Thus, AEL in its native form promotes selective antitumor effects in human breast cancer cells and may represent a potential therapeutic to combat human breast cancer.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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