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Abstract Title:

Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia-Reperfusion Injury.

Abstract Source:

Nutr Metab Insights. 2016 ;9:25-30. Epub 2016 Jun 20. PMID: 27375360

Abstract Author(s):

Janelle L Davis, Hunter L Paris, Joseph W Beals, Scott E Binns, Gregory R Giordano, Rebecca L Scalzo, Melani M Schweder, Emek Blair, Christopher Bell

Article Affiliation:

Janelle L Davis

Abstract:

Intravenous administration of vitamin C has been shown to decrease oxidative stress and, in some instances, improve physiological function in adult humans. Oral vitamin C administration is typically less effective than intravenous, due in part to inferior vitamin C bioavailability. The purpose of this study was to determine the efficacy of oral delivery of vitamin C encapsulated in liposomes. On 4 separate randomly ordered occasions, 11 men and women were administered an oral placebo, or 4 g of vitamin C via oral, oral liposomal, or intravenous delivery. The data indicate that oral delivery of 4 g of vitamin C encapsulated in liposomes (1) produces circulating concentrations of vitamin C that are greater than unencapsulated oral but less than intravenous administration and (2) provides protection from ischemia-reperfusion-mediated oxidative stress that is similar to the protection provided by unencapsulated oral and intravenous administrations.

Study Type : Human Study

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Sayer Ji
Founder of GreenMedInfo.com

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