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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study.

Abstract Source:

J Biochem Mol Toxicol. 2018 Apr 16:e22053. Epub 2018 Apr 16. PMID: 29660801

Abstract Author(s):

Oytun Erbaş, Mümin Alper Erdoğan, Asghar Khalilnezhad, Volkan Solmaz, Fulya Tuzcu Gürkan, Gürkan Yiğittürk, Hüseyin Avni Eroglu, Dilek Taskiran

Article Affiliation:

Oytun Erbaş

Abstract:

The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group (n = 6) received regular tap water, whereas other groups received aspartame (3 mg/kg/day, n = 6,) or saccharin (3 mg/kg/day, n = 6) or sucralose (1.5 mg/kg/day, n = 6) in the drinking water. Following 6 weeks, the passive avoidance learning (PAL) test was performed to evaluate the neurobehavioral effects of sweeteners. The brains were assessed for lipid peroxides, neuron count, and Glial fibrillary acidic protein (GFAP) immunohistochemistry. Our results demonstrated that chronic intake of sweeteners significantly impaired PAL performance in all groups. Hippocampal CA1-CA3 areas revealed significantly lower neuronal count in aspartame and increased GFAP expression in all groups. Brain lipid peroxides were significantly higher in all groups. Our findings suggest that long-term consumption of artificial sweeteners may have harmful effects on cognition and hippocampal integrity inrats.

Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Neurotoxic : CK(1396) : AC(289)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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