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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Low dose bisphenol S or ethinyl estradiol exposures during the perinatal period alter female mouse mammary gland development.

Abstract Source:

Reprod Toxicol. 2018 Mar 8. Epub 2018 Mar 8. PMID: 29526645

Abstract Author(s):

SriDurgaDevi Kolla, Mary Morcos, Brian Martin, Laura N Vandenberg

Article Affiliation:

SriDurgaDevi Kolla

Abstract:

Throughout life, mammary tissue is strongly influenced by hormones. Scientists have hypothesized that synthetic chemicals with hormonal activities could disrupt mammary gland development and contribute to breast diseases and dysfunction. Bisphenol S (BPS) is an estrogenic compound used in many consumer products. In this study, CD-1 mice were exposed to BPS (2 or 200 μg/kg/day) during pregnancy and lactation. Mice exposed to 0.01 or 1 μg/kg/day ethinyl estradiol (EE2), a pharmaceutical estrogen, were also evaluated. Mammary glands from female offspring were collected prior to the onset of puberty, during puberty, and in early adulthood. Growth parameters,histopathology, cell proliferation and expression of hormone receptors were quantified. Our evaluations revealed age- and dose-specific effects of BPS that were different from the effects of EE2, and distinct from the effects of BPA that have been reported previously. These assessments suggest thatindividual xenoestrogens may have unique effects on this sensitive tissue.

Study Type : Animal Study
Additional Links
Problem Substances : Bisphenol A : CK(685) : AC(178)

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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