Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves you essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

Abstract Title:

Low-dose gamma irradiation of food protein increases its allergenicity in a chronic oral challenge.

Abstract Source:

Food Chem Toxicol. 2012 Sep 19 ;51C:46-52. Epub 2012 Sep 19. PMID: 23000443

Abstract Author(s):

A F M Vaz, M P Souza, P L Medeiros, A M M A Melo, R A Silva-Lucca, L A Santana, M L V Oliva, K R Perez, I M Cuccovia, M T S Correia

Article Affiliation:

Unidade Acadêmica de Medicina Veterinária, CSTR, Universidade Federal de Campina Grande, Patos, Paraíba, Brazil; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, Brazil. Electronic address: melo_vaz@ig.com.br.

Abstract:

Few chronic food protein models have described the relationship between allergenicity and the molecular structure of food protein after physical processing. The effect ofγ-radiation on the structure of food protein was measured by fluorescence, circular dichroism and microcalorimetry. BALB/c mice were intraperitoneally sensitized and then given non-irradiated and irradiated Con-A by daily gavage for 28days. The tendency to form insoluble amorphous aggregates and partially unfolded species was observed after irradiation. The administration of non-irradiated and irradiated samples at low-dose significantly increased weight loss as well as plasma levels of eotaxin in animals repeatedly exposed to Con-A. Significant lymphocytic infiltrate filling completely the stroma of microvilli and tubular glands was observed in the small intestinal of the group given Con-A irradiated at a low dose. This phenotype was not observed in animals treated with Con-A irradiated at a high dose.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves you essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2017 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.