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Abstract Title:

Low-Dose Pesticide Mixture Induces Senescence in Normal Mesenchymal Stem Cells (MSC) and Promotes Tumorigenic Phenotype in Premalignant MSC.

Abstract Source:

Stem Cells. 2017 Mar ;35(3):800-811. Epub 2016 Nov 23. PMID: 27860054

Abstract Author(s):

Mazene Hochane, Valerie Trichet, Claire Pecqueur, Pierre Avril, Lisa Oliver, Jerome Denis, Regis Brion, Jerome Amiaud, Alain Pineau, Philippe Naveilhan, Dominique Heymann, François M Vallette, Christophe Olivier

Article Affiliation:

Mazene Hochane

Abstract:

Humans are chronically exposed to multiple environmental pollutants such as pesticides with no significant evidence about the safety of such poly-exposures. We exposed mesenchymal stem cells (MSC) to very low doses of mixture of seven pesticides frequently detected in food samples for 21 days in vitro. We observed a permanent phenotype modification with a specific induction of an oxidative stress-related senescence. Pesticide mixture also induced a shift in MSC differentiation towards adipogenesis but did not initiate a tumorigenic transformation. In modified MSC in which a premalignant phenotype was induced, the exposure to pesticide mixture promoted tumorigenic phenotype both in vitro and in vivo after cell implantation, in all nude mice. Our results suggest that a common combination of pesticides can induce a premature ageing of adult MSC, and as such could accelerate age-related diseases. Exposure to pesticide mixture may also promote the tumorigenic transformation in a predisposed stromal environment. Abstract Video Link: https://youtu.be/mfSVPTol-Gk Stem Cells 2017;35:800-811.

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Sayer Ji
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