Low levels of selenium, fluoride and arsenic are toxic to rat embryos. - GreenMedInfo Summary

Abstract Title:

[The toxicity of combination of selenium, fluoride and arsenic on rat embryos].

Abstract Source:

Wei Sheng Yan Jiu. 1999 Mar 30;28(2):74-6. PMID: 11939006

Abstract Author(s):

Y Li, M Sun, D Wu, X Chen

Article Affiliation:

National Center for Material and Infant Health, Beijing Medical University, Beijing 100083, China.

Abstract:

Whole embryo rotated culture technique was used to investigate the toxicity of combination of selenium, fluoride and arsenic on rat embryos at day 9.5 of gestation. The result of factorial analysis (3 x 3 x 3) showed that the main effect of combination of selenium, fluoride and arsenic on the developmental toxicity was synergistic. The mixtures with different level of these three chemicals in combination could result in different developmental toxicity. The low level combinations mainly caused teratogenic effect, and the high level combinations(selenium 2.0 micrograms + fluoride 10 micrograms + arsenic 1.0 microgram/ml culture media) caused lethal effect. The results suggested that the disorders of yolk-sac placenta in structure and function were one of teratogenic mechanisms for the combination of selenium, fluoride and arsenic.

Article Published Date : Mar 30, 1999
Study Type : Animal Study
Additional Links
Diseases : Birth Defects : CK(196) : AC(37), Prenatal Chemical Exposures : CK(322) : AC(86)
Additional Keywords : Drug Synergy : CK(327) : AC(147)
Problem Substances : Arsenic : CK(82) : AC(12), Fluoride : CK(264) : AC(45), Sodium Selenate : CK(11) : AC(8), Sodium Selenite : CK(21) : AC(15)
Adverse Pharmacological Actions : Teratogenic : CK(304) : AC(59)

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