Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Lysergic acid diethylamide and psilocybin for the management of patients with persistent pain: a potential role?

Abstract Source:

Pain Manag. 2018 May 3. Epub 2018 May 3. PMID: 29722608

Abstract Author(s):

Andy Whelan, Mark I Johnson

Article Affiliation:

Andy Whelan

Abstract:

Recently, there has been interest in lysergic acid diethylamide (LSD) and psilocybin for depression, anxiety and fear of death in terminal illness. The aim of this review is to discuss the potential use of LSD and psilocybin for patients with persistent pain. LSD and psilocybin are 5-hydroxytryptamine receptor agonists and may interact with nociceptive and antinociceptive processing. Tentative evidence from a systematic review suggests that LSD (7 studies, 323 participants) and psilocybin (3 studies, 92 participants) may be beneficial for depression and anxiety associated with distress in life-threatening diseases. LSD and psilocybin are generally safe if administered by a healthcare professional, although further investigations are needed to assess their utility for patients with persistent pain, especially associated with terminal illness.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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