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Abstract Title:

[Preventive effects of lutein on liver toxicity in mice induced by arsenic].

Abstract Source:

Wei Sheng Yan Jiu. 2015 Jul ;44(4):615-9. PMID: 26454960

Abstract Author(s):

Mingke Niu, Shugang Li, Qiang Niu, Shangzhi Xu, Jiaonan Xiao, Li Ding, Jiaqing Liu, Hui Wen, Gangling Feng

Article Affiliation:

Mingke Niu

Abstract:

OBJECTIVE: To explore the intervention effects of lutein on liver toxicity in mice induced by arsenic trioxide (As2O3) and to evaluate the preventive effect and the antioxidant mechanism of lutein.

METHODS: A total of 84 healthy KM mice were randomly divided into eight groups. There were 35 d control group, 70 d control group, 35 d lutein group, 70 d lutein group, arsenic exposure group, lutein treatment group and lutein prevention group. The activity and level of AST, ALT, T-AOC, MDA, GSH, SOD, NO in liver tissue were measured by kits. Compares the difference between each group of the single factor analysis of variance.

RESULTS: The activity of ALT, AST and the contents of MDA of 70 d control group were significantly lower than that arsenic exposure group. The contents of GSH, T-AOC, NO and the activity of SOD of 70 d control group were increased significantly than arsenic exposure group. The activity of ALT, AST and the contents of MDA of lutein prevention group were significantly lower than that lutein treatment group. The contents of GSH, T-AOC, NO and the activity of SOD of lutein prevention group were increased significantly than lutein treatment group. The differences were statistically significant (P<0.05).

CONCLUSION: Lutein can improve antioxidation function and has protective effect on liver injury of mice induced by arsenic.

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