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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Kidney-protective Effect of Magnesium Supplementation in Cisplatin-containing Chemotherapy for Pediatric Cancer: A Retrospective Study.

Abstract Source:

J Pediatr Hematol Oncol. 2018 Apr 20. Epub 2018 Apr 20. PMID: 29683958

Abstract Author(s):

Motohiro Matsui, Yuya Saito, Shoko Yamaoka, Yuichi Yokokawa, Yoshihiko Morikawa, Atsushi Makimoto, Yuki Yuza

Article Affiliation:

Motohiro Matsui

Abstract:

In total, 158 chemotherapy courses containing cisplatin for 37 pediatric cases of newly diagnosed cancer were divided into 2 groups depending on whether magnesium (Mg) supplementation was administered (Mg+: 92 courses) or not (Mg-: 66 courses). Renal impairment was defined as grade 2 or higher creatinine elevation (CE) after each chemotherapy course. The incidence of CE in the Mg+ was significantly lower than in the Mg- (9.8% vs. 22.7%; P=0.025). Multivariate analysis revealed that Mg supplementation significantly reduced the incidence of CE (odds ratio, 0.36; confidence interval, 0.13-0.99). In pediatric patients, Mg supplementation during cisplatin-containing chemotherapy was associated with less cisplatin-induced nephrotoxicity to prevent cisplatin-induced nephrotoxicity.

Study Type : Human Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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