Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

Abstract Title:

DNA double-strand breaks induced by mammographic screening procedures in human mammary epithelial cells.

Abstract Source:

Int J Radiat Biol. 2011 Jul 29. Epub 2011 Jul 29. PMID: 21797809

Abstract Author(s):

Catherine Colin, Clément Devic, Alain Noël, Muriel Rabilloud, Marie-Thérèse Zabot, Sylvie Pinet-Isaac, Sophie Giraud, Benjamin Riche, Pierre-Jean Valette, Claire Rodriguez-Lafrasse, Nicolas Foray

Abstract:

Abstract Purpose: To assess in vitro mammographic radiation-induced DNA damage in mammary epithelial cells from 30 patients with low (LR) or high (HR) family risk of breast cancer. Materials and methods: Spontaneous and radiation-induced DNA double-strand breaks (DSB) were quantified by using immunofluorescence of the phosphorylated H2AX histone (γH2AX) in different conditions of mammography irradiation (2, 4, 2+2 mGy). Results: HR patients showed significantly more spontaneous γH2AX foci than LR patients (p=0.014). A significant dose-effect was observed, with an exacerbation in HR patients (p=0.01). The dose repetition (2+2 mGy) providedmore induced and more unrepaired DSB than 2 mGy and 4 mGy, and was exacerbated in HR (p=0.006). Conclusions: This study highlights the existence of DSB induced by mammography and revealed by γH2AX assay with two major radiobiological effects occurring: a low-dose effect, and a LOw and Repeated Dose(LORD) effect. All these effects were exacerbated in HR patients. These findings may lead us to re-evaluate the number of views performed in screening using a single view (oblique) in women whose mammographic benefit has not properly been proved such as the 40-49 and HR patients.

Study Type : Human Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2017 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.