Abstract Title:

Mangiferin inhibits passive cutaneous anaphylaxis reaction and pruritus in mice.

Abstract Source:

Planta Med. 2009 Oct;75(13):1415-7. Epub 2009 Jun 16. PMID: 19533581

Abstract Author(s):

Bomi Lee, Hien Trung Trinh, Eun-Ah Bae, Kangshik Jung, Dong-Hyun Kim

Article Affiliation:

Department of Life and Nanopharmaceutical Sciences, Kyung Hee University Dongdaemun-ku, Seoul, Korea.

Abstract:

The antiallergic effect of mangiferin isolated from the rhizome of Anemarrhena asphodeloides Bunge (family Liliaceae) was measured in vitro and in vivo. Orally and intraperitoneally administered mangiferin potently inhibited passive cutaneous anaphylaxis (PCA) reaction induced by IgE-antigen complex as well as pruritus induced by compound 48/80 in mice. Mangiferin also inhibited the expression of the proinflammatory cytokine TNF-alpha and the IgE-switching cytokine IL-4 as well as transcription factor NF-kappaB activation in RBL-2H3 cells stimulated by IgE-antigen complex. These findings suggest that mangiferin may improve PCA reaction and pruritus.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.